Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell Carcinoma
Identifieur interne : 003649 ( Main/Exploration ); précédent : 003648; suivant : 003650Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor Receptor-3 Correlates with Lymphangiogenesis and Angiogenesis and Affects Survival of Oral Squamous Cell Carcinoma
Auteurs : Chao Li [République populaire de Chine] ; Jinchuan Fan [République populaire de Chine] ; Xicheng Song [République populaire de Chine] ; Bing Zhang [République populaire de Chine] ; Yu Chen [République populaire de Chine] ; Chunhua Li [République populaire de Chine] ; Kun Mi [République populaire de Chine] ; Hong Ma [République populaire de Chine] ; Yufeng Song [République populaire de Chine] ; Xiaofeng Tao [République populaire de Chine] ; Guojun Li [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Both Ang-2 and VEGFR-3 are major regulators of angiogenesis and lymphangiogenesis, respectively, and thus may affect prognosis of OSCC. We sought to determine the associations between Ang-2 and VEGFR-3 expression and survival of OSCC.
Ang-2 and VEGFR-3 expression was determined immunohistochemically in tumor tissues from 112 patients with OSCC; OSCC-adjacent noncancerous oral tissue from 85 OSCC patients; and normal oral mucosa from 37 cancer-free individuals. A log-rank test and Cox proportional hazard models were used to compare survival among different groups with expression of Ang-2 and VEGFR-3.
Ang-2 and VEGFR-3 expression was upregulated in OSCC compared to nontumor tissue (all
These results suggest that increased expression in tumors of Ang-2 may individually, or in combination with VEGFR-3, predict poor prognosis of OSCC.
Url:
DOI: 10.1371/journal.pone.0075388
PubMed: 24040410
PubMed Central: 3770542
Affiliations:
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Diseases in Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Jinchuan" sort="Fan, Jinchuan" uniqKey="Fan J" first="Jinchuan" last="Fan">Jinchuan Fan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Song, Xicheng" sort="Song, Xicheng" uniqKey="Song X" first="Xicheng" last="Song">Xicheng Song</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Qingdao University, Yantai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Qingdao University, Yantai</wicri:regionArea><wicri:noRegion>Yantai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan, China</addr-line></nlm:aff><country 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xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Hong" sort="Ma, Hong" uniqKey="Ma H" first="Hong" last="Ma">Hong Ma</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang</wicri:regionArea><wicri:noRegion>Guiyang</wicri:noRegion></affiliation></author><author><name sortKey="Song, Yufeng" sort="Song, Yufeng" uniqKey="Song Y" first="Yufeng" last="Song">Yufeng Song</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang</wicri:regionArea><wicri:noRegion>Guiyang</wicri:noRegion></affiliation></author><author><name sortKey="Tao, Xiaofeng" sort="Tao, Xiaofeng" uniqKey="Tao X" first="Xiaofeng" last="Tao">Xiaofeng Tao</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai JIaoTong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai JIaoTong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Li, Guojun" sort="Li, Guojun" uniqKey="Li G" first="Guojun" last="Li">Guojun Li</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Head and Neck Surgery, U.T. M.D. Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Head and Neck Surgery, U.T. 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wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Fan, Jinchuan" sort="Fan, Jinchuan" uniqKey="Fan J" first="Jinchuan" last="Fan">Jinchuan Fan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Song, Xicheng" sort="Song, Xicheng" uniqKey="Song X" first="Xicheng" last="Song">Xicheng Song</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Qingdao University, Yantai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital, Qingdao University, Yantai</wicri:regionArea><wicri:noRegion>Yantai</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oral Diseases in Sichuan University, Sichuan</wicri:regionArea><wicri:noRegion>Sichuan</wicri:noRegion></affiliation></author><author><name sortKey="Li, Chunhua" sort="Li, Chunhua" uniqKey="Li C" first="Chunhua" last="Li">Chunhua Li</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Mi, Kun" sort="Mi, Kun" uniqKey="Mi K" first="Kun" last="Mi">Kun Mi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Hong" sort="Ma, Hong" uniqKey="Ma H" first="Hong" last="Ma">Hong Ma</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang</wicri:regionArea><wicri:noRegion>Guiyang</wicri:noRegion></affiliation></author><author><name sortKey="Song, Yufeng" sort="Song, Yufeng" uniqKey="Song Y" first="Yufeng" last="Song">Yufeng Song</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Oral and Maxillary Surgery, the Affiliated Hospital of Guiyang Medical College, Guiyang</wicri:regionArea><wicri:noRegion>Guiyang</wicri:noRegion></affiliation></author><author><name sortKey="Tao, Xiaofeng" sort="Tao, Xiaofeng" uniqKey="Tao X" first="Xiaofeng" last="Tao">Xiaofeng Tao</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai JIaoTong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Radiology Department of Shanghai Ninth People's Hospital Affiliated Shanghai JIaoTong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Li, Guojun" sort="Li, Guojun" uniqKey="Li G" first="Guojun" last="Li">Guojun Li</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Head and Neck Surgery, U.T. M.D. Anderson Cancer Center, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Head and Neck Surgery, U.T. M.D. Anderson Cancer Center, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Both Ang-2 and VEGFR-3 are major regulators of angiogenesis and lymphangiogenesis, respectively, and thus may affect prognosis of OSCC. We sought to determine the associations between Ang-2 and VEGFR-3 expression and survival of OSCC.</p></sec><sec><title>Methods</title><p>Ang-2 and VEGFR-3 expression was determined immunohistochemically in tumor tissues from 112 patients with OSCC; OSCC-adjacent noncancerous oral tissue from 85 OSCC patients; and normal oral mucosa from 37 cancer-free individuals. A log-rank test and Cox proportional hazard models were used to compare survival among different groups with expression of Ang-2 and VEGFR-3.</p></sec><sec><title>Results</title><p>Ang-2 and VEGFR-3 expression was upregulated in OSCC compared to nontumor tissue (all <italic>P</italic><0.05). High Ang-2 expression positively correlated with microvessel density (MVD) (<italic>P</italic><0.01), and high VEGFR-3 expression positively correlated with lymph node metastasis (<italic>P</italic><0.01) and lymphatic vessel density (LVD) (<italic>P</italic><0.01). The patients with high expression of Ang-2 alone or in combination with VEGFR-3 had a significantly worse survival than in patients with low expression of Ang-2 or any other co-expression status (all <italic>P</italic><0.05), respectively. Furthermore, multivariable analysis showed that patients with high expression of Ang-2 alone or in combination with VEGFR-3 had a significantly increased risk of death compared with those with low expression of Ang-2 or any other co-expression status (HR, 2.7, 95% CI, 1.1–6.2 and 5.0, 1.3–15.4, respectively).</p></sec><sec><title>Conclusions</title><p>These results suggest that increased expression in tumors of Ang-2 may individually, or in combination with VEGFR-3, predict poor prognosis of OSCC.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Massano, J" uniqKey="Massano J">J Massano</name></author><author><name sortKey="Regateiro, Fs" uniqKey="Regateiro F">FS Regateiro</name></author><author><name sortKey="Januario, G" uniqKey="Januario G">G Januário</name></author><author><name sortKey="Ferreira, A" uniqKey="Ferreira A">A Ferreira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gale, 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Wiegand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="M Kinen, T" uniqKey="M Kinen T">T Mäkinen</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Veikkola, T" uniqKey="Veikkola T">T Veikkola</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Kettunen, Mi" uniqKey="Kettunen M">MI Kettunen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wigle, Jt" uniqKey="Wigle J">JT Wigle</name></author><author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holopainen, T" uniqKey="Holopainen T">T Holopainen</name></author><author><name sortKey="Saharinen, P" uniqKey="Saharinen P">P Saharinen</name></author><author><name sortKey="D Amico, G" uniqKey="D Amico G">G D'Amico</name></author><author><name sortKey="Lampinen, A" uniqKey="Lampinen A">A Lampinen</name></author><author><name sortKey="Eklund, L" uniqKey="Eklund L">L Eklund</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name></noRegion><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><name sortKey="Fan, Jinchuan" sort="Fan, Jinchuan" uniqKey="Fan J" first="Jinchuan" last="Fan">Jinchuan Fan</name><name sortKey="Li, Chao" sort="Li, Chao" uniqKey="Li C" first="Chao" last="Li">Chao Li</name><name sortKey="Li, Chunhua" sort="Li, Chunhua" uniqKey="Li C" first="Chunhua" last="Li">Chunhua Li</name><name sortKey="Ma, Hong" sort="Ma, Hong" uniqKey="Ma H" first="Hong" last="Ma">Hong Ma</name><name sortKey="Mi, Kun" sort="Mi, Kun" uniqKey="Mi K" first="Kun" last="Mi">Kun Mi</name><name sortKey="Song, Xicheng" sort="Song, Xicheng" uniqKey="Song X" first="Xicheng" last="Song">Xicheng Song</name><name sortKey="Song, Yufeng" sort="Song, Yufeng" uniqKey="Song Y" first="Yufeng" last="Song">Yufeng Song</name><name sortKey="Tao, Xiaofeng" sort="Tao, Xiaofeng" uniqKey="Tao X" first="Xiaofeng" last="Tao">Xiaofeng Tao</name><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Li, Guojun" sort="Li, Guojun" uniqKey="Li G" first="Guojun" last="Li">Guojun Li</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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